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Utilizing a microfluidic chip with serpentine channels, we inoculated the chip with an agar plug with Neurospora crassa mycelium and successfully captured individual hyphae in channels. For the first time, we report the presence of an autonomous clock in hyphae. Fluorescence of a mCherry reporter gene driven by a clock-controlled gene-2 promoter (ccg-2p) was measured simultaneously along hyphae every half an hour for at least 6 days. We entrained single hyphae to light over a wide range of day lengths, including 6,12, 24, and 36 h days. Hyphae tracked in individual serpentine channels were highly synchronized (K = 0.60-0.78). Furthermore, hyphae also displayed temperature compensation properties, where the oscillation period was stable over a physiological range of temperatures from 24 °C to 30 °C (Q10 = 1.00-1.10). A Clock Tube Model developed could mimic hyphal growth observed in the serpentine chip and provides a mechanism for the stable banding patterns seen in race tubes at the macroscopic scale and synchronization through molecules riding the growth wave in the device. 

Human visual grouping processes consolidate independent visual objects into grouped visual features on the basis of shared characteristics; these visual features can themselves be grouped, resulting in a hierarchical representation of visual grouping information. This “grouping hierarchy“ promotes ef- ficient attention in the support of goal-directed behavior, but improper grouping of elements of a visual scene can also re- sult in critical behavioral errors. Understanding of how visual object/features characteristics such as size and form influences perception of hierarchical visual groups can further theory of human visual grouping behavior and contribute to effective in- terface design. In the present study, participants provided free- response groupings of a set of stimuli that contained consistent structural relationships between a limited set of visual features. These grouping patterns were evaluated for relationships be- tween specific characteristics of the constituent visual features and the distribution of features across levels of the indicated grouping hierarchy. We observed that while the relative size of the visual features differentiated groupings across levels of the grouping hierarchy, the form of visual objects and features was more likely to distinguish separate groups within a partic- ular level of hierarchy. These consistent relationships between visual feature characteristics and placement within a grouping hierarchy can be leveraged to advance computational theories of human visual grouping behavior, which can in turn be ap- plied to effective design for interfaces such as voter ballots. 

Human visual grouping processes consolidate independent visual objects into grouped visual features on the basis of shared characteristics; these visual features can themselves be grouped, resulting in a hierarchical representation of visual grouping information. This “grouping hierarchy“ promotes ef- ficient attention in the support of goal-directed behavior, but improper grouping of elements of a visual scene can also re- sult in critical behavioral errors. Understanding of how visual object/features characteristics such as size and form influences perception of hierarchical visual groups can further theory of human visual grouping behavior and contribute to effective in- terface design. In the present study, participants provided free- response groupings of a set of stimuli that contained consistent structural relationships between a limited set of visual features. These grouping patterns were evaluated for relationships be- tween specific characteristics of the constituent visual features and the distribution of features across levels of the indicated grouping hierarchy. We observed that while the relative size of the visual features differentiated groupings across levels of the grouping hierarchy, the form of visual objects and features was more likely to distinguish separate groups within a partic- ular level of hierarchy. These consistent relationships between visual feature characteristics and placement within a grouping hierarchy can be leveraged to advance computational theories of human visual grouping behavior, which can in turn be ap- plied to effective design for interfaces such as voter ballots. 

The use of a microwell microfluidic device allows separating single cells and tracking single cells data. The measurement of single cell fluorescent intensity trajectories in the microwell device supported a deterministic quorum sensing model identified by ensemble methods for clock phase synchronization. A strong inference framework was used to test the communication mechanism in phase synchronization of quorum sensing versus cell-to-cell contact, and the results lent support for quorum sensing. 

Four inter-related measures of phase are described to study the phase synchronization of cellular oscillators, and computation of these measures is described and illustrated on single cell fluorescence data from the model filamentous fungus, Neurospora crassa. One of these four measures is the phase shift ϕ in a sinusoid of the form x(t) = A(cos(ωt + ϕ), where t is time. The other measures arise by creating a replica of the periodic process x(t) called the Hilbert transform x̃(t), which is 90 degrees out of phase with the original process x(t). The second phase measure is the phase angle FH(t) between the replica x̃(t) and X(t), taking values between -π and π. At extreme values the Hilbert Phase is discontinuous, and a continuous form FC(t) of the Hilbert Phase is used, measuring time on the nonnegative real axis (t). The continuous Hilbert Phase FC(t) is used to define the phase MC(t1,t0) for an experiment beginning at time t0 and ending at time t1. In that phase differences at time t0 are often of ancillary interest, the Hilbert Phase FC(t0) is subtracted from FC(t1). This difference is divided by 2π to obtain the phase MC(t1,t0) in cycles. Both the Hilbert Phase FC(t) and the phase MC(t1,t0) are functions of time and useful in studying when oscillators phase-synchronize in time in signal processing and circadian rhythms in particular. The phase of cellular clocks is fundamentally different from circadian clocks at the macroscopic scale because there is an hourly cycle superimposed on the circadian cycle. 

This paper presents a search for massive, charged, long-lived particles with the ATLAS detector at the Large Hadron Collider using an integrated luminosity of $$140~fb^{−1}$$ of proton-proton collisions at $$\sqrt{s}=13$$~TeV. These particles are expected to move significantly slower than the speed of light. In this paper, two signal regions provide complementary sensitivity. In one region, events are selected with at least one charged-particle track with high transverse momentum, large specific ionisation measured in the pixel detector, and time of flight to the hadronic calorimeter inconsistent with the speed of light. In the other region, events are selected with at least two tracks of opposite charge which both have a high transverse momentum and an anomalously large specific ionisation. The search is sensitive to particles with lifetimes greater than about 3 ns with masses ranging from 200 GeV to 3 TeV. The results are interpreted to set constraints on the supersymmetric pair production of long-lived R-hadrons, charginos and staus, with mass limits extending beyond those from previous searches in broad ranges of lifetime 

This report presents a comprehensive collection of searches for new physics performed by the ATLAS Collaboration during the Run~2 period of data taking at the Large Hadron Collider, from 2015 to 2018, corresponding to about 140~$$^{-1}$$ of $$\sqrt{s}=13$$~TeV proton--proton collision data. These searches cover a variety of beyond-the-standard model topics such as dark matter candidates, new vector bosons, hidden-sector particles, leptoquarks, or vector-like quarks, among others. Searches for supersymmetric particles or extended Higgs sectors are explicitly excluded as these are the subject of separate reports by the Collaboration. For each topic, the most relevant searches are described, focusing on their importance and sensitivity and, when appropriate, highlighting the experimental techniques employed. In addition to the description of each analysis, complementary searches are compared, and the overall sensitivity of the ATLAS experiment to each type of new physics is discussed. Summary plots and statistical combinations of multiple searches are included whenever possible. 

Top-quark pair production is observed in lead–lead ( $\mathrm{Pb}+\mathrm{Pb}$) collisions at $\sqrt{s_{\mathrm{NN}}}=5.02\mathrm{TeV}$at the Large Hadron Collider with the ATLAS detector. The data sample was recorded in 2015 and 2018, amounting to an integrated luminosity of $1.9{\mathrm{nb}}^{-1}$. Events with exactly one electron and one muon and at least two jets are selected. Top-quark pair production is measured with an observed (expected) significance of 5.0 (4.1) standard deviations. The measured top-quark pair production cross section is ${\sigma }_{t\overline{t}}=3.6{}_{-0.9}^{+1.0}\left(\mathrm{stat}\right){}_{-0.5}^{+0.8}\left(\mathrm{syst}\right)\mathrm{\mu }\mathrm{b}$, with a total relative uncertainty of 31%, and is consistent with theoretical predictions using a range of different nuclear parton distribution functions. The observation of this process consolidates the evidence of the existence of all quark flavors in the preequilibrium stage of the quark-gluon plasma at very high energy densities, similar to the conditions present in the early Universe. © 2025 CERN, for the ATLAS Collaboration2025CERN